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Learn about the side effects of Zoloft (sertraline), from common to rare, for consumers and healthcare professionals. Sertraline ER Tablets package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology. Zoloft package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology. Información para el paciente sobre Zoloft: para qué sirve, dosis, efectos secundarios y cómo usar este medicamento. Detailed dosage guidelines and administration information for Zoloft (sertraline hydrochloride). Includes dose adjustments, warnings and precautions. Sertraline (Zoloft) is an SSRI used to treat depression, anxiety, OCD, PTSD, and PMDD by increasing serotonin levels to improve mood and emotional balance. Zoloft is an antidepressant used to treat major depression, obsessive-compulsive disorder, panic disorder, social anxiety, and post-traumatic stress disorder. Easy-to-read patient leaflet for Zoloft (Sertraline Tablets). Includes indications, proper use, special instructions, precautions, and possible side effects. Easy-to-read patient tips for Zoloft covering how it works, benefits, risks, and best practices. Zoloft User Reviews & Ratings Zoloft has an average rating of 7.3 out of 10 from a total of 1,996 reviews on Drugs.com. 64% of reviewers reported a positive experience, while 18% reported a negative experience.