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(transitive) To be unable to follow or trace (somebody or something) any longer. lose verb (NO LONGER POSSESS) [ T ] to no longer have something, because it has been taken away from you, either by accident or purposely: Lose definition: To be unsuccessful in retaining possession of; mislay. Many English learners confuse lose, loss, and lost because these words come from the same root but serve different grammatical roles. If you lose something, you do not know where it is, for example, because you have forgotten where you put it. I lost my keys. LOSE definition: to come to be without (something in one's possession or care), through accident, theft, etc., so that there is little or no prospect of recovery. See examples of lose used in a sentence. 2. to fail to keep or maintain: to lose one's balance. 3. to suffer the loss or deprivation of: to lose a parent. lose (lo̅o̅z), v., lost, los•ing. v.t. to come to be without (something in one's possession or care), through accident, theft, etc., so that there is little or no prospect of recovery: I'm sure I've merely misplaced my hat, not lost it. The meaning of LOSE is to miss from one's possession or from a customary or supposed place. How to use lose in a sentence. Definition of lose verb in Oxford Advanced American Dictionary. Meaning, pronunciation, picture, example sentences, grammar, usage notes, synonyms and more.