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Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube. u noun or U / ˈjuː/ plural u's or U's / ˈjuːz/ Britannica Dictionary definition of U 1 : the 21st letter of the English alphabet U (minuscule: u) is the twenty-first letter and the fifth vowel letter of the Latin alphabet, used in the modern English alphabet and the alphabets of other western European languages and others worldwide. U definition: the 21st letter of the English alphabet, a vowel. See examples of U used in a sentence. The letter U is a descendant of the letter V, which is discussed later in this volume. Relatives of U are F, W, and Y. The original forms of the sign in the Egyptian hieroglyphic, Phoenician, and Greek writings are shown in the illustrations numbered (1), (2), and (3) respectively. The Latin letter u. Did you know? Words Starting With U Browse 8,266 words and phrases that start with the letter U, from uakari to Uzbek.