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Oxycodone vs Hydrocodone: Direct Comparison Multiple studies show oxycodone and hydrocodone provide equivalent pain relief for both cancer-related and acute severe pain (such as fractures), and 5 mg oxycodone = 5 mg hydrocodone. What is the difference between oxycodone and Oxycontin? Oxycodone (also known as Oxy IR) and Oxycontin both contain oxycodone, but the main difference is that Oxycontin is the brand name of a long-acting form of oxycodone. Oxycontin releases oxycodone slowly and continuously over 12 hours and only needs to be given twice a day. Oxycodone is shorter-acting, with an average half-life of 3.2. Learn about the side effects of oxycodone, from common to rare, for consumers and healthcare professionals. Easy-to-read patient tips for oxycodone covering how it works, benefits, risks, and best practices. Oxycodone package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology. Información para el paciente sobre Oxycodone: para qué sirve, dosis, efectos secundarios y cómo usar este medicamento. OxyContin (oxycodone) is an opioid pain reliever used to treat moderate to severe pain. Includes OxyContin side effects, dose, uses and more. Detailed Oxycodone dosage information for adults and children. Includes dosages for Pain and Chronic Pain; plus renal, liver and dialysis adjustments. Oxycodone is an opioid pain medication used to treat moderate to severe pain. Includes oxycodone side effects, dose, reviews, warnings, and more. Roxicodone (oxycodone) is an opioid pain medication used to treat moderate to severe pain. Includes Roxicodone side effects, interactions, and indications.