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DIFFERENCE definition: the state or relation of being different; dissimilarity. See examples of difference used in a sentence. The meaning of DIFFERENCE is the quality or state of being dissimilar or different. How to use difference in a sentence. Noun difference (countable and uncountable, plural differences) (uncountable) The quality of being different. The difference between two things is the way in which they are unlike each other. Definition of difference noun in Oxford Advanced Learner's Dictionary. Meaning, pronunciation, picture, example sentences, grammar, usage notes, synonyms and more. the degree to which one person or thing differs from another: [countable; usually singular] The difference in their ages is about six months. [uncountable] There isn't much difference between one politician and another. To distinguish or differentiate. These nouns refer to a lack of correspondence or agreement. Difference is the most general: differences in color and size; a difference of degree but not of kind. difference definition: characteristic that distinguishes one thing from another. Check meanings, examples, usage tips, pronunciation, domains, and related words. Discover expressions like same difference , it makes no difference , what's the difference. DIFFERENCE definition: 1. the way in which two or more things which you are comparing are not the same: 2. a…. Learn more. Difference definition: The quality or condition of being unlike or dissimilar.