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Cubs -179, Cardinals +149; over/under is 9 runs BOTTOM LINE: The Chicago Cubs host the St. Louis Cardinals to open a three-game series. Chicago has a 47-31 record at home and an 89-70 record overall. View the St. Louis Cardinals vs. Chicago Cubs game played on September 27, 2025. Box score, stats, play-by-play timeline, highlights, odds & more Game summary of the Chicago Cubs vs. St. Louis Cardinals MLB game, final score 12-1, from September 26, 2025 on ESPN. The Cardinals–Cubs rivalry, also called the Route 66 rivalry and The I-55 rivalry, refers to the rivalry between the St. Louis Cardinals and Chicago Cubs of the National League (NL), one of the most bitter rivalries in Major League Baseball and in all of North American professional sports. CBS Sports brings you live coverage, scoring, expert picks and stats for the MLB matchup between St. Louis Cardinals and Chicago Cubs on September 26, 2025 The official website of the St. Louis Cardinals with the most up-to-date information on news, tickets, schedule, stadium, roster, rumors, scores, and stats. Chicago Cubs beat St. Louis Cardinals (2-0). Sep 28, 2025, Attendance: 37497, Time of Game: 2:02. Visit Baseball-Reference.com for the complete box score, play-by-play, and win probability.

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